A practical roadmap to stabilize, avoid common triggers, and support recovery from Post Finasteride Syndrome and related conditions (PSSD / PAS, Post-Lions Mane and Post Ashwaganda Syndromes)—step by step.

PSSD - Post SSRI Sexual Disfunction

PAS - Post Accutane Syndrome

News / Research
Recovery Roadmap
Recovery Anecdotes
Reported Crash Patterns Overview
Reported Crash Patterns Substance Directory
Learn More about the mechanism of PFS PSSD PAS
Learn More About Mechanism of Post Lion's Mane Disorder
  • "Hold on - Healing isn't linear."

  • "I've been worse. I've improved before. I am not done."

  • "Even broken, I keep going."

  • "I can carry this and still build a life."

  • "I refuse to quit on myself."

Recovery Roadmap

  • After PFS/PSSD/PAS begins, some medications, supplements, creams, herbs, and personal care products that were previously “safe” can trigger crashes/flares or slow recovery. Because they didn’t cause issues before, they’re often overlooked.

    Step 1: Identify triggers and simplify to stabilize.


    See the Reported Crash Patterns Overview and Reported Crash Patterns Substance Directory below for commonly reported triggers.

    How to do it (when safe):

    • Pause potential trigger supplements and products for a short period

    • Keep your routine minimal and consistent

    • Only add something back if you truly need it

    • Before reintroducing, research the item (and consult a clinician when appropriate)

    • Reintroduce one item at a time so any triggering substance is obvious

  • Once triggers are removed, many people find that time, a simpler routine, and an individualized diet can reduce symptoms—sometimes leading to major improvement or remission.

    Key points:

    • Focus on consistency + time after removing triggers

    • Use a simple, personalized diet that you tolerate well

    • Many people benefit from reducing or removing: sugar, dairy, gluten, and processed foods

    • If you reach stable recovery, continue avoiding:

      • the substance(s) that caused your condition, and

      • any triggers listed in Reported Crash Patterns Overview below

  • If you’ve stabilized as much as you can and still feel stuck, you may see people discussing “protocols” or targeted interventions. These can carry real downside, and results are highly variable, so the safest framing is risk management: avoid impulsive changes, start with the most conservative options, and introduce only one variable at a time. Whenever possible, involve a clinician—especially for prescription meds, hormones, research chemicals, or anything requiring labs/monitoring.

    It is important to note that removing triggering substances, a healthy diet and lifestyle, and time, sometimes several years are the most common factors involved in improvement. There are many anecdotes of worsening from protocols as there is not scientifically proven cure for these conditions and no protocol with repeatable, consistent results has been identified.

Substance Risk Signals (Based on Community Reports)

Substances Commonly Linked to Lasting Worsening (Community Reports)

In community reports, these substances are more often described as triggering severe symptom escalations (“crashes”)that sometimes do not fully return to prior baseline.

Described outcomes may include persistent or semi-persistent worsening of core symptoms such as sexual dysfunction, emotional blunting/anhedonia, cognitive impairment, and stress intolerance.

This classification reflects frequency and severity of reported outcomes, not proven causation or population-wide risk. Individual responses vary widely.

Substances More Often Linked to Temporary Flares (Community Reports)

In community discussions, these substances are more commonly associated with symptom flares—temporary worsening that often improves after discontinuation and time to stabilize.

Some individuals still report significant or prolonged reactions, but lasting baseline deterioration is reported less frequently than in the group above.

These patterns are observational and vary greatly by dose, formulation, timing, and individual sensitivity.

*Community observations suggest that repeatedly starting and stopping substances—rather than steady avoidance—may be associated with greater destabilization in some individuals. Repeated exposures may stress already fragile regulatory systems and are often described as riskier than consistent avoidance with time for recovery.

Important: These groupings reflect reported patterns, not guarantees. A substance listed here may be tolerated by some individuals and poorly tolerated by others. This page is intended to help readers contextualize anecdotal risk, not to replace medical judgment.

Substance Risk Signals Directory (Community Reports)

More Often Linked to Lasting Worsening (Community Reports)

Some reports describe persistent worsening

Click a substance for the summary, citations, and community anecdotes.

Aromatase Inhibitors (AIs)
Ashwaganda
Atypicals including Mirtazapine, trazodone, vortioxetine
Creatine
Finasteride / Dutasteride Oral & Topical
Ecstasy / Molly
Hair Vitamins / Nutrafol
Ginger (Extract)
Inositol
High Risk Antibiotics
Lion's Mane
Ketoconazole & Hair Loss Shampoo
Melissa officinalis (Lemon Balm)
MAOIs
Natural DHT Blockers: reishi, stinging nettle etc.
Pygeum
Rogaine / Minoxidil
Saw Palmetto
Shrooms
Spironolactone
St. John's Wort
SSRis & SNRIs
Tretinoin / Vitamin A Derivatives
Wellbutrin
5-HTP & Same-E
Vorinostat
Panax Ginseng
ALCAR
Sodium Butyrate
Dopamine Agonists / Pramipexole
Zuranolone (Allopreg)
Opioids / Xanax
Hair Loss / Thickening Shampoos (Tea tree oil)
Ginko Biloba
High Dose Vitamin C
Hydroxyzine
Licorice Root
Retinol Cream
Rosemary & Lavender
Saffron
SARMS
BPC-157
Vitamin D
Lamictal
9-ME-BC
L-Carnitine
Probiotics
Beta Blockers
Pregnenelone & DHEA
Antipsychotics
Accutane

More Often Linked to Temporary Flares (Community Reports)

Often improves after stopping

Click a substance for the summary, citations, and community anecdotes.

Antifungals "Azole" Class
Alcohol, Cannabis / Weed
Turmeric (Curcumin)
Rhodiola Rosea
Caffeine
Cyproheptadine
Gabapentin
Ginger (Food)
Tea & Extracts (Green Tea, Licorice, Peppermint)
Beta Blockers
NAD+
Boron
Zinc

*This is community-reported sensitivity. Individual responses vary. Not medical advice.These groupings reflect reported patterns, not proven causation or probability. Individual responses vary widely.

Recovery / Improvement Anecdotes Database

How to Interpret This Section

There are currently no approved protocols, proven cures, or controlled clinical studies demonstrating a reliable treatment for PFS/PSSD/PAS. Reported improvements vary widely between individuals, and outcomes are inconsistent and unpredictable.

This section compiles mentions from self-reported recovery or improvement stories. A mention does not mean the substance caused the improvement, is safe, or will help others. Many recoveries involve multiple changes at once (time, stopping a trigger, diet/sleep changes, other medications or supplements), and reporting bias is common. Some items listed here have also been associated with flares or worsening in other reports.

How to use it: Treat this as a research index (what people tried and what they said happened), not a recommendation list. If you choose to test anything, do it cautiously and discuss it with a licensed clinician.

Inclusion criteria: “Listed here = appears in at least one publicly available anecdote describing improvement.”

Substances Mentioned in Reported Improvements

(Anecdotal mentions from self-reports — click a button to see sources and context.)

Time
Diet
Gut Protocols
FMT (Fecal Matter Transplant)
Testosterone
Estrogen
Kisspeptin
Proviron
Post Cycle Therapy (PCT)
SIBO Treatment
Ketamine
Citrulline
BAT (Bipolar Androgen Therapy)
Tribulus
NSI-189
Tongkat Ali
Xifaxan (rifaximin)
L Glutamine
Water Based Testosterone
Reinstatement (Extreme Crash Risk)
Shrooms (moderate crash risk)
St. Johns Wart (extreme crash risk)
Inositol (high crash risk)
DHT w/ E2
DHB & Sodium Valproate
HCG
Lithium
Addyi (flibanserin)
HGH
Low Dose Naltrexone (LDN)
Progesterone
Cold Exposure
Hops (Humulus lupulus)
Maca (Lepidium meyenii)
Viagra / Cialis

Mixed Reports: Improvement Mentions + Severe Worsening Reports

Recovery Anecdote Sources

(clickable buttons below)

Improvement Anecdotes Compiled 1
Improvement Anecdotes Compiled 2
Improvement Anecdotes Compiled 3
MESO 2023 PSSD Recovery Anecdote Spreadsheet
Bron Fog FMT Recovery
Ryan Russo DHB Valproate Recovery

Research & Community Updates

(clickable buttons below)

Disclaimer: This page is for tracking research and community anecdotes. It does not recommend any treatment or self-experimentation. Many items listed are unproven and some can cause harm or symptom worsening. Discuss any medical changes with a licensed clinician.

Research & Publications (Primary Sources)

Dr. Josef Youtube
PSSD NETWORK RESEARCH PAPER LINK (MELCANGI STUDIES)
Moral Medicine Youtube
Propecia Help Forum (Research Updates At Top)
Dr. Will Powers PFS Theory

*Propecia Help Results From 2 Studies coming 2026 (See Propecia Help Link)

  • Epigenetic Study Results Teaser: “While we cannot reveal specifics, early signals are promising, with clear differences between patient samples and controls. Researchers have commented the results are unusually clear for this type of work”

Community Active Experiments (Anecdotal / High Variability)

DHT w/ E2
FMT (Fecal Matter Transplant)
Low Dose Flumazenil IV
DHB & Sodium Valproate
3% Cover the Fee

Contact Us

If you have feedback on the site, questions, or would like to share your experience, feel free to reach out. Messages related to site improvements, clarification, or support requests are always welcome.

postfinasterideguide@gmail.com

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