Boron
Boron is a trace mineral found naturally in foods (especially fruits, vegetables, nuts, and legumes) and in drinking water. It’s commonly sold as a supplement in small milligram doses and is usually marketed for “testosterone support,” bone health, or inflammation-related benefits. Compared with many “hormone” supplements, boron often looks innocuous on paper—but it can still have measurable endocrine effects in some contexts, especially at higher supplemental doses.
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This page summarizes anecdotal reports and community observations, not medical evidence. Reports may be incomplete, biased or inaccurate and are not medical advice or recommendations. “Risk” here refers to how frequently severe or prolonged symptom worsening is reported, not to proven causation or population-wide probability. Individual responses vary widely, and absence of issues in some users does not rule out significant reactions in others.
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Within PFS/PSSD/PAS communities, boron is discussed in relation to its potential interactions with sex-hormone signaling pathways. Mechanistically, boron has been reported in small human studies to shift sex-hormone markers over short timeframes (for example: reduced SHBG and higher free testosterone, alongside lower estradiol after about a week in a small sample). It's also worth noting that "boron effects" are not consistent across all studies/populations, so it's better framed as a potential endocrine nudge rather than a predictable lever. These mechanisms may interact with pathways involving SHBG binding, free testosterone dynamics, or estradiol regulation that are often discussed in relation to PFS / PSSD / PAS.
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Mixed Responses With Mild Hormone-Sensitivity Risks (for PFS/PSSD/PAS):
Among individuals with PFS, PSSD, or PAS, boron is generally described as a milder, hormone-adjacent supplement with mixed outcomes. Some users report small or subtle benefits such as slight improvements in libido, mood, or overall “androgenic feel,” while many report no meaningful change. A smaller subset describe flares or destabilization, most often involving anxiety, sleep disruption, feeling wired or unstable, or increased volatility in sexual symptoms.
Although boron is often viewed as lower risk than stronger endocrine or serotonergic agents, it is not considered biologically neutral in an androgen-sensitive population, as it may influence free testosterone or estradiol dynamics in some individuals. As a result, it is commonly treated as a variable-response supplement rather than a safe default, with caution advised at higher doses or when stacked with other hormone-active substances. During periods of instability, many within the community recommend avoiding experimentation altogether or keeping exposure minimal and short-term.
Evidence basis: small human hormone-marker studies and general safety literature; community anecdotes and self-reports. No controlled studies specific to PFS, PSSD, or PAS.
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Public comments reflect individual experiences and opinions. They are not medical advice and may not be accurate or representative.